University at Buffalo
The Witebsky Center

The Witebsky Center
University at Buffalo
Bacteriology hostmicrobe immunology parasitology virology bioinformatics mycology
The Witebsky Center The Witebsky Center
Virology

Participating Faculty:
John Hay, Ph.D., Amy Jacobs, Ph.D., Thomas Melendy, Ph.D.


Close collaboration between the Hay and Ruyechan laboratories has yielded detailed insights into the pathways of Varicella Zoster Virus (VZV) gene expression and its regulation. Further studies combining both molecular genetic approaches and animal model systems are directed toward development of a more efficacious VZV vaccine. Herpes Simplex Virus DNA replication is an additional focus of the Ruyechan laboratory. DNA replication studies are also being conducted in the Melendy laboratory. Both SV40 and papilloma virus model systems are being exploited to elucidate details of the steps employed in initiation of replication. Research in the Hay laboratory is designed to elucidate the pathway of Hantaan virus glycoprotein trafficking and virus assembly.

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