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Participating Faculty:
John Hay, Ph.D., Thomas Melendy, Ph.D., Edward G. Niles, Ph.D., William T. Ruyechan, Ph.D.
Close collaboration between
the Hay and Ruyechan
laboratories has yielded detailed insights into the pathways
of Varicella Zoster Virus (VZV) gene expression and its regulation.
Further studies combining both molecular genetic approaches
and animal model systems are directed toward development of
a more efficacious VZV vaccine. Herpes Simplex Virus DNA replication
is an additional focus of the Ruyechan
laboratory. DNA replication studies are also being conducted
in the Melendy laboratory.
Both SV40 and papilloma virus model systems are being exploited
to elucidate details of the steps employed in initiation of
replication. Vaccinia virus gene expression is a major focus
of the Niles laboratory.
Mechanisms of poxvirus mRNA processing and transcription termination
are the subjects of intense investigation. Recently, structure
function studies of the Hantaan virus L protein were initiated
in the Niles laboratory.
This work compliments ongoing research in the Hay
laboratory designed to elucidate the pathway of Hantaan virus
glycoprotein trafficking and virus assembly.
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