Stefan Ruhl, Ph.D.
Department of Oral Biology
School of Dental Medicine
University at Buffalo
3435 Main Street
Foster Hall, Room 213A
Phone: (716) 829-6073
Our laboratory is interested in the proteins of human saliva that are recognized by microbial adhesins. It is our long-term goal to better understand the modulating role of salivary glycoproteins in supporting tissue tropism of a benign commensal oral microflora to the human oral cavity and in host defense against pathogenic microorganisms.
A detailed description of our current research activities can be found on the following website: http://www.sdm.buffalo.edu/oralbiology/home.asp?f=shruhl
Bürgers R, Schneider-Brachert W, Reischl U, Behr A, Hiller K-A, Lehn N, Schmalz G, Ruhl S (2008) Helicobacter pylori in human oral cavity and stomach. Eur. J. Oral Sci. 116:297-304.
Müller R, Ruhl S, Hiller K-A, Schmalz G, Schweikl H (2007) Adhesion of eukaryotic cells and Staphylococcus aureus to silicon model surfaces. J. Biomed. Mater. Res. A. 84A: 817-827.
Müller R, Gröger G, Hiller K-A, Schmalz G, Ruhl S (2007) Fluorescence-based bacterial overlay method for simultaneous in situ quantification of surface-attached bacteria. Appl. Environ. Microbiol. 73: 2653-2660.
Müller R, Hiller K-A, Schmalz G, Ruhl S (2006) Chemiluminescence-based detection and comparison of protein amounts adsorbed on differently modified silica surfaces. Anal. Biochem. 359: 194-202.
Aspholm M, Kalia A, Ruhl S, Schedin S, Arnqvist A, Sjöström R, Gerhard M, Semino-Mora C, Dubois A, Unemo M, Danielsson D, Teneberg S, Kon W, Berg D, Borén T (2006) Helicobacter pylori adhesion to carbohydrates. Meth. Enzymol. 417: 293-339.
Walz A, Wattenberg A, Meyer HE, Schmalz G, Blüggel M, Ruhl S (2006) Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis. Proteomics 6: 1631-1639.
Walz A, Odenbreit S, Mahdavi J, Borén T, Ruhl S (2005) Identification and characterization of binding properties of Helicobacter pylori by glycoconjugate arrays. Glycobiology 15: 700-708.
Ruhl S, Rayment SA, Schmalz G, Hiller K-A and Troxler RF (2005) Proteins in whole saliva during the first year of infancy. J. Dent. Res. 84: 29-34.
Ruhl S, Sandberg AL and Cisar JO (2004) Salivary receptors for the proline rich protein-binding and lectin-like adhesins of oral actinomyces and streptococci. J. Dent. Res. 83: 505-510.
Ruhl S, Hamberger S, Betz R, Sukkar T, Schmalz G, Seymour RA, Hiller K-A and Thomason JM (2004) Salivary proteins and cytokines in drug-induced gingival overgrowth. J. Dent. Res. 83: 322-326.
Takahashi Y, Ruhl S, Yoon J-W, Sandberg AL and Cisar JO (2002) Adhesion of viridans group streptococci to sialic acid-, galactose- and N-acetylgalactosamine-containing receptors. Oral Microbiol. Immunol. 17: 257-262.
Ruhl S, Cisar JO, Sandberg AL (2000) Identification of polymorphonuclear leukocyte and HL-60 cell receptors for adhesins of Streptococcus gordonii and Actinomyces naeslundii. Infect. Immun. 68: 6346-6354.
Takahashi Y, Sandberg AL, Ruhl S, Muller J, and Cisar JO (1997) A specific cell surface antigen of Streptococcus gordonii is associated with bacterial hemagglutination and adhesion to a2-3-linked sialic acid-containing receptors. Infect. Immun. 65: 5042-5051.
Ruhl S, Sandberg AL, Cole MF, and Cisar JO (1996) Recognition of IgA1 by oral actinomyces and streptococcal lectins. Infect. Immun. 64: 5421-5424.
Sandberg AL, Ruhl S, Joralmon RA, Brennan MJ, Sutphin MJ, and Cisar JO (1995) Putative glycoprotein and glycolipid polymorphonuclear leukocyte receptors for the Actinomyces naeslundii WVU45 lectin. Infect. Immun. 63: 2625-2631.
Ruhl S, Feldman GM, Akahane K, and Pluznik DH (1993) Interferon-g antagonizes interleukin-6-induced expression of interleukin-4 receptors in murine myeloid cells by a transcriptional mechanism. Blood 82: 2641-2648.
Ruhl S, Pluznik DH, and Feldman GM (1993) Soluble interleukin-4 receptor production by murine myeloid progenitor cells: induction by interleukin-6 and interferon-g. Cytokine 5: 144-149.
Ruhl S and Pluznik DH (1993) Dissociation of early and late markers of murine myeloid differentiation by interferon-gamma and interleukin-6. J. Cell. Physiol. 155: 130-138.
Ruhl S, Schwabe M, and Pluznik DH (1992) Interleukin-1 augments the expression of interleukin-2 receptors on differentiating myeloid cells. Exp. Hematol. 20: 1208-1215.
Ruhl S, Begley CG, Bickel M, and Pluznik DH (1992) Transient expression of the IL-2 receptor a-chain in IL-6-induced myeloid cells is regulated by autocrine production of prostaglandin E2. Exp. Hematol. 20: 619-625.
Feldman GM, Ruhl S, Bickel M, Finbloom D, and Pluznik DH (1991) Regulation of interleukin-4 receptors on murine myeloid progenitor cells by interleukin-6. Blood 78: 1678-1684.
Bickel M, Dveksler G, Dieffenbach CW, Ruhl S, Midura SB, and Pluznik DH (1990) Induction of interferon-b and 2'5'-oligoadenylate synthetase mRNA by interleukin-6 during differentiation of murine myeloid cells. Cytokine 2: 1-9.
Najar HM, Ruhl S, Bru-Capdeville AC, and Peters JH (1990) Adenosine and its derivates control human monocyte differentiation into highly accessory cells versus macrophages. J. Leuk. Biol. 47: 429-439.
Peters JH, Ruhl S, and Friedrichs D (1987) Veiled accessory cells deduced from monocytes.
Immunobiol. 176: 154-166.