University at Buffalo
The Witebsky Center

The Witebsky Center
 
 
University at Buffalo
Bacteriology Host-Microbe Interactions Immunology Parasitology Virology
The Witebsky Center The Witebsky Center
Andrew M. Gulick, Ph.D.

Sr. Research Scientist
Hauptman-Woodward Institute
700 Ellicott St.
Buffalo, New York 14203

Assistant Professor, Department of Stuctural Biology, University at Buffalo
700 Ellicott St.
Buffalo, New York 14203

Email: gulick@hwi.buffalo.edu
Telephone Number: 716-898-8619
Fax: 716-898-8660

http://labs.hwi.buffalo.edu/gulick
www.hwi.buffalo.edu/faculy_research/Gulick/gulick.html

 
 
Synopsis of Research

 

The research in our lab focuses on bacterial pathways that are responsible for the synthesis of natural products that play important roles in virulence and pathogenesis. Our work uses biochemical, genetic, and structural techniques to explore the function of novel enzymes that catalyze interesting biochemical reactions. A major effort is to use X-ray crystallography to determine the molecular structures of these enzymes and to characterize the ability of small molecule inhibitors to interact with these proteins.

Biosynthetic pathways under study in the lab include those that are responsible for the production of peptide siderophores, molecules that bacteria produce to bind iron and enable the acquisition of this important metal nutrient. These compounds are produced by large, modular enzymes known as non-ribosomal peptide synthetases that use an assembly line synthetic strategy. We are investigating the fundamental biochemical mechanisms of these enzymes to understand the molecular choreography they use to coordinate the activities of multiple domains. Additionally, we are studying specific inhibitors that block the enzymes that catalyze important steps in siderophore synthesis. These studies aim to develop specific chemical tools that we can use to further investigate the role that siderophores play in bacterial growth and pathogenesis.

 

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