Modulatory Effects of Retinoids on Immunoglobulin Synthesis and B Cell  Function.  These studies involve examining the effects of retinoic acid on cytokine synthesis and the mechanisms by which retinoids augment immunoglobulin synthesis. (Support-University Pediatric Associates Special Funds)

Supplementation of Very Low Birthweight Premature Infants with  Vitamin A.  This study is designed to examine the effects of Vitamin A supplementation in preterm infants to determine if Vitamin A is able to enhance the maturational process of the humoral immune system of preterm infants. (Support-NIH, 4 years, total funding: $829,466)

The Immunology of Chronic Sinusitis.  These studies are aimed at a better understanding of the immunological responses of adenoidal tissues, and to determine the immune deviations in young children who are prone to recurrent or chronic sinus disease.

Clinical Investigative Studies with Intravenous Immune Serum Globulin Therapy.  We are involved in a Phase 3 trials of a new intravenous immune serum globulin (IVIG) in patients with common variable immunodeficiency disease. (Support-Immune Deficiency Foundation)

Evaluation of Medication Compliance in an Inner City Population of Asthmatic Children.  This is a study to determine whether medication compliance or adherence is different between an oral leukotriene modifier vs. inhaled corticosteroids, in children age 6 to 18 with asthma. (Support-Merck)