cordially invited to attend
the Department of Pathology and Anatomical Sciences
15th annual lecture in honor of Kornel L. Terplan, M.D.
TITLE: Infection and Autoimmunity
We are studying two well-defined models of autoimmune disease, thyroiditis and myocarditis. In both diseases, the induction depends upon a combination of genetic and environmental factors. The principal trait determining susceptibility to autoimmune disease is the major histocompatibility complex (MHC), but additional non-MHC genes are also involved. As environmental factors, dietary iodine is a trigger for thyroiditis and Coxsackievirus infection instigates myocarditis. To determine the pathological consequences of autoimmune responses, we are concentrating on particular cytokines and cytokine receptors. These experiments depend upon examining the local production of cytokines in autoimmune infiltrates, producing cytokines locally by constructing transgenic mice, and blocking cytokine action by administration of monoclonal antibodies or receptor antagonists. In parallel to experiments in mice, we are carrying out correlative investigations in patient populations.
by Noel R. Rose, MD, PhD bio
Director, Center for Autoimmune Diseases
Departments of Pathology & Molecular Biology/Immunology
Johns Hopkins University
144 Farber Hall
UB South Campus map
Date and Time
October 16, 2014
A reception immediately follows lecture. All are invited. rsvp