Images of Musculoskeletal Oncology

Periosteal OGS
A 17 year old girl with three months of increasing pain, swelling, and limited range of shoulder motion.

This radiograph demonstrates a dense bone forming lesion involving the medial proximal aspect of her right humerus with extensive medial extension into her right axilla.
Angiograms demonstrate the medial displacement of the axillary artery.
Photomicrographs of a core needle biopsy revealing a combination of new tumor, bone, pleomorphic cartilage and malignant cells. This peripheral location of a malignant bone tumor containing large amounts of cartilage strongly suggests the diagnosis of a periosteal osteogenic sarcoma. A wide resection was performed with a delay in planned reconstruction.

The architecture of this lesion is best seen in lab radiographs of the resected specimen.
Recurrence developed at two to three months despite chemotherapy. Amputation was recommended and initially refused, but done for palliation at six years following local resection.
On the amputation specimen note the intimate connection of the brachial plexus and this tumor. This connection made wide resection almost impossible. The patient eventually died with widespread metastases about seven years after she began treatment.
This large histosection demonstrates the tumor's peripheral location; note the large cartilage masses.
Learning Issues:

Periosteal osteogenic sarcoma is said to lie biologically somewhere between parosteal osteogenic and conventional osteogenic sarcoma. The intimate connection with the brachial plexus made limb sparing a difficult goal to achieve; perhaps early forequarter amputation would have been a better choice.


Images of Musculoskeletal Oncology
University at Buffalo Department of Orthopaedics