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Dr.
Seigel's lab
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Dr. Gail M. Seigel
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Research Hightlight - Stem cells are valuable Biomedical
research tools for the study of cell growth and differentiation.
In addition, stem cell research holds clinical promise in
the development of genetic and cell replacement therapies.
The overall theme of my research program has been the study
of ocular stem cells and precursor cells in order to isolate,
establish and characterize cell lines with basic and clinical
applications in Ophthalmology. Our laboratory is best known
for the R28 retinal precursor cell line, available to academic
laboratories for collaborative studies. The cells have been
shared with over 80 laboratories world-wide and are the subject
of numerous peer-reviewed articles. Please contact Dr. Seigel
for more information at gseigel@frontiernet.net
The Heidelberg HRA2 ophthalmoscope is used to obtain
high-resolution retinal images. By obtaining these images,
we hope to improve strategies for earlier diagnosis
of retinal degenerative diseases, such as Batten Disease.
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 Retinoblastoma
cells express cancer stem cell markers. The bright red
cells are immunopositive for ABCG2, a marker of
chemo-resistance, that also causes the exclusion of
Hoechst 33342 dye. Hoechst 33342 dye is taken up by
non-stem cells (seen in blue).
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Resources and suppliers
Please contact Dr. Seigel for more information at gseigel@frontiernet.net
People
Gail M. Seigel, Ph.D., Principal Investigator
Lorrie M. Campbell, Technician
Facilities
Sherman 312, 322 and 310A on UB South Campus. We have excellent
facilities for cell culture, microscopy, imaging, immunohistochemistry
and western immunoblotting.
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