OFFICE LOCATIONS

Administrative Office 1176 Main Street Buffalo, NY 14209 Phone: 716-881-7916 Contact: Elaine Taylor Email: etaylor@buffalo.edu View map Patient Care Office - University Ophthalmology 1176 Main Street Buffalo, NY 14209 Phone: 716-881-7916 Contact: Elaine Taylor Email: etaylor@buffalo.edu View map

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DESCRIPTION OF INTERESTS

Dr. Reynolds has various research interests in pediatric ophthalmology, but his main niche is retinopathy of prematurity. ROP is a disease of the developing immature retinal vasculature, modulated by hyperoxia/hypoxia micro environments in the retina, which can lead to neovascularization, scarring, and potential blindness. Dr. Reynolds is a recognized expert in the field and is the author of many peer reviewed articles and several invited review chapters. His NIH funding has been nearly continuous while at U.B. while participating in several multi-center clinical trials in ROP as center P.I. and project director. Dr. Reynolds was the center P.I. at U.B. for the first large treatment trial for ROP, CRYO-ROP. This trial established the first known effective treatment for this high socioeconomic impact disease. As center P.I. he participated in the group collaborative publications as well as co authoring many individually by-lined papers (Ref. 22, 23, 24, 25, 26, 28, 29, 31, 32, 37, 40, 42). His successful and productive work as a center P.I. on this trial led to the funding for the LIGHT-ROP multi-center trial for which he served as project director and lead P.I. This trial definitively answered a long debated hypothesis in ROP i.e. that ambient light was not a causal factor in ROP (Ref. 38, 41, 45, 47). Dr. Reynolds was again selected as a center P.I. for the next large multi-center ROP trial, ET-ROP, which just reported its primary results demonstrating that earlier laser treatment for this disease was effective. Although all multi-center clinical trials are cooperative agreements at the NIH and thus are funded as UO1s rather than RO1s, Dr. Reynolds was an integral participant in all the ROP trials from the mid-eighties to the present, leading one, and actively co-authoring many of the publications as noted in the bibliography. The future of Dr. Reynolds' ROP research will undoubtedly involve more funded multi-center trials. However, a basic science collaboration into the pathophysiology of ROP in an animal model is planned.

SPECIALTIES

Ophthalmology Pediatric Ophthalmology Retina Pathophysiology

EDUCATION

1982 Fellowship, Pediatric Ophthalmology University of Pittsburgh 1981 Residency, Ophthalmology SUNY/Buffalo 1978 Doctor of Medicine, SUNY/Buffalo 1974 Bachelor of Arts, Biology SUNY/Buffalo

PUBLICATIONS

Reynolds JD, Quinn GE; Eye to Eye Retinopathy of Prematurity; J of Ped Ophthalmol & Strabismus; 2004; 41; Phan MH, Nguyen PN, Reynolds JD; Incidence and severity of retinopathy of prematurity in Vietnam, a developing middle-income country.; J Pediatr Ophthalmol Strabismus; 2003; 40(4); 208-212 Reynolds JD, Dobson V, Quinn GE, Fielder AR, Palmer EA, Saunders RA, Hardy RJ, Phelps DL, Baker JD, Trese MT, Schaffer D, Tung B; Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies.; Arch Ophthalmol; 2002 Nov; 120(11); 1470-1476 Fielder AR, Reynolds JD; Retinopathy of prematurity: clinical aspects.; Semin Neonatol; 2001 Dec; 6(6); 461-475 Kennedy KA, Fielder AR, Hardy RJ, Tung B, Gordon DC, Reynolds JD; Reduced lighting does not improve medical outcomes in very low birth weightinfants.; J Pediatr; 2001 Oct; 139(4); 527-531 James Reynolds; The Management of Retinopathy of Prematurity; Paediatric Drugs; 2001; 3(4); 263-272 Msall ME, Phelps DL, DiGaudio KM, Dobson V, Tung B, McClead RE, Quinn GE, Reynolds JD, Hardy RJ, Palmer EA; Severity of neonatal retinopathy of prematurity is predictive of neurodevelopmental functional outcome at age 5.5 years. Behalf of the Cryotherapy for Retinopathy of Prematurity Cooperative Group.; Pediatrics; 2000 Nov; 106(5); 998-1005 Reynolds JD; Abduction Deficits in Strabismus; Am Orthoptic Journal; 2000; 50; 7 Dobson V, Quinn GE, Siatkowski RM, Baker JD, Hardy RJ, Reynolds JD, Trese MT, Tung B; Agreement between grating acuity at age 1 year and Snellen acuity at age 5.5 years in the preterm child. Cryotherapy for Retinopathy of Prematurity Cooperative Group.; Invest Ophthalmol Vis Sci; 1999 Feb; 40(2); 496-503 Reynolds JD; Management of Intermittent Exotropia; NYSight; 1999; Reynolds JD; The LIGHT-ROP Cooperative Group: The Design of the Multicenter Study of Light Reduction in Retinopathy of Prematurity (LIGHT-ROP); J. Ped. Ophthalmol. & Strabismus; 1999; 36(5); 257-263 Quinn GE, Dobson V, Kivlin J, Kaufman LM, Repka MX, Reynolds JD, Gordon RA, Hardy RJ, Tung B, Stone RA; Prevalence of myopia between 3 months and 5 1/2 years in preterm infants with and without retinopathy of prematurity. Cryotherapy for Retinopathy of Prematurity Cooperative Group.; Ophthalmology; 1998 Jul; 105(7); 1292-1300 Olitsky SE, Vilardo M, Awner S, Reynolds JD; Needle sterility during strabismus surgery.; J AAPOS; 1998 Jun; 2(3); 151-152 Reynolds JD, Hardy RJ, Kennedy KA, Spencer R, van Heuven WA, Fielder AR; Lack of efficacy of light reduction in preventing retinopathy of prematurity. Light Reduction in Retinopathy of Prematurity (LIGHT-ROP) Cooperative Group.; N Engl J Med; 1998 May; 338(22); 1572-1576 Reynolds JD, Olitsky SE, Awner S; Perioperative Care of the Strabismus Patient; J. Ped. Ophthalmol. Strabismus; 1997 Jan; 34; 126-128 Reynolds JD, Olitsky SE, Sadler LS; Subnormal Binocular Vision in the Williams Syndrome; J. Ped. Ophthalmol. Strabismus; 1997 Jan; 34; 1-3 Sadler LS, Olitsky SE, Reynolds JD; Reduced stereoacuity in Williams syndrome.; Am J Med Genet; 1996 Dec; 66(3); 287-288 Reynolds JD, Abrams MS, Olitsky SE; Accommodative Esotropia Following Surgery for Congenital Esotropia; Binocular Vision; 1996 Jan; 11; 195-198 Reynolds JD; Cryotherapy for Retinopathy of Prematurity Group: Multicenter Trial of Cryotherapy for ROP: Snellen Visual Acuity and Structural Outcome at 5.5 years After Randomization; Archives of Ophthalmology; 1996; 114; 417-424 Reynolds JD, Gilbert WS, Quinn GE, Dobson V, Hardy RJ, Palmer EA; Partial Retinal Detachment at 3 Months after Threshold ROP: Long Term Structural and Functional Outcome; Archives of Ophthalmology; 1996 Jan; 114; 1091 James Reynolds; Retinopathy of Prematurity; Ophthalmology Clinics of North America; 1996; 9(2); 149-159 Dobson V, Quinn GE, Tung B, Palmer EA, Reynolds JD; Comparison of recognition and grating acuities in very-low-birth-weight children with and without retinal residua of retinopathy of prematurity. Cryotherapy for Retinopathy of Prematurity Cooperative Group.; Invest Ophthalmol Vis Sci; 1995 Mar; 36(3); 692-702 Reynolds JD; 3. Reynolds, JD: When Should Children Be Examined? Proceedings of the International Conference on Retinopathy of Prematurity; Kluger Publishing. Amsterdam, New York; 1995; James Reynolds; Pediatric Glaucoma; Pediatric Ophthalmology and Strabismus; 1995; Reynolds JD, Wackerhagen MV; Results of Strabismus Surgery in Pre-term vs. Full term children; Binocular Vision; 1995 Jan; 10; 21-24 Reynolds JD; Selection of an Area to Perform The Examination. Proceedings of the International Conference on Retinopathy of Prematurity; Kluger Publishing. Amsterdam, New York; 1995; Reynolds JD, Dobson V, Quinn GE, Gilbert WS, Tung B, Flynn JT; Visual Function and Structure in ROP. Proceedings of the International Conference on Retinopathy of Prematurity; Kluger Publishing. Amsterdam, New York; 1995; Reynolds JD; Who Should Perform the Examination? Proceedings of the International Conference on Retinopathy of Prematurity; Kluger Publishing Amsterdam, New York; 1995; Reynolds JD; Cryotherapy for Retinopathy of Prematurity Group: The Natural Ocular Outcome of Premature Birth and Retinopathy: Status at One Year; Arch Ophthalmol; 1994; 112; 903-912 Reynolds JD, Wackerhagen MV, Olitsky SE; Overminus Lens for Intermittent Exotropia; Am Orthoptic J; 1994 Jan; 44; 86-91 Reynolds JD; Cryotherapy for Retinopathy of Prematurity Cooperative Group: Multicenter Trial of Cryotherapy for Retinopathy of Prematurity, 3 ½ Year Outcome-Structure and Function; Arch Ophthalmol; 1993; 111; 339-344 Reynolds JD, Dobson V, Quinn GE, Gilbert WS, Tung B, Robertson J, Flynn JT; Prediction of Visual Function in Eyes with Mild to Moderate Posterior Pole Residua of ROP.; Arch Ophthalmol; 1993 Jan; 111; 1056 Reynolds JD, Quinn GE, Dobson V, Repka MX, Kivlin J, Davis B, Buckley E, Flynn JT, Palmer EA; Development of Myopia in Infants with Birth Weights Less Than 1251 Grams; Ophthalmology; 1992 Jan; 99; 329-340 Reynolds JD; Ophthalmology. In Brodsky, L. ed: Craniofacial Anomalies: An Interdisciplinary Approach; C.V. Mosby; 1992; Reynolds JD, Glibert WS, Dobson V, Quinn GE, Tung B, Flynn JT; The Correlation of Visual Function with Posterior Retinal Structure in Severe Retinopathy of Prematurity; Arch Ophthalmol; 1992 Jan; 110; 625-631 Reynolds JD; Anisometropic Amblyopia in Severe Posterior Retinopathy of Prematurity; Binocular Vision; 1990; 5(3); 153-158 Reynolds JD; Cryotherapy for Retinopathy of Prematurity Cooperative Group: Multicenter Trial of Cryotherapy for Retinopathy of Prematurity. One Year Outcome - Structure and Function; Arch Ophthalmol; 1990; 108; 1408-1416 Reynolds JD, Underwood DW; Anomalous Insertion of the Superior Oblique Tendon.; Binocular Vision; 1989 Jan; 4(2); 76-80 Reynolds JD, Johnson BL, Gloster S, Biglan AW; Glaucoma and Klippel-Trenaunay-Weber syndrome.; Am J Ophthalmol; 1988 Oct; 106(4); 494-496 Reynolds JD, Wackerhagen MV; Early onset Exotropia; Am Orthoptic J; 1988 Jan; 38; 94-100 Reynolds JD, Wackerhagen MV; Duane’s Syndrome with Accommodative Component; Am. Orthoptic J; 1987 Jan; 37; 95-99 Reynolds JD, Wackerhagen MV; Superior Oblique Tenotomy in Patients with Fusion; Binocular Vision; 1987 Jan; 3(1); 33-39 Reynolds JD; Visual acuity after treatment of persistent hyperplastic primary vitreous.; Arch Ophthalmol; 1986 Sep; 104; 1274-1275 Reynolds JD, Griebel M, Mallory S, Steele R; Congenital herpes simplex retinitis.; Am J Ophthalmol; 1986 Jul; 102(1); 33-36 Reynolds JD, Wackerhagen MV; Case corner - Intermittent Exotropia Case Study; Am Orthoptic Journal; 1986; 36; 175-181 Reynolds JD; Nasal Superior Oblique Tenotomy via a Temporal Approach for A-Pattern Strabismus; Binocular Vision; 1986; 1(3); 127-134 Reynolds JD, Wackerhagen MV; Strabismus in Monozygotic and Dizygotic Twins; Am. Orthoptic J; 1986 Jan; 36; 113-119 Reynolds JD, Wackerhagen M, Petursson G; The role of the primary care physician in eye care.; J Ark Med Soc; 1985 Nov; 82(6); 256-258 Woody RC, Reynolds JD; Association of bilateral internuclear ophthalmoplegia and myelomeningocele with Arnold-Chiari malformation, type II.; J Clin Neuroophthalmol; 1985 Jun; 5(2); 124-126 Newton NL, Reynolds JD, Woody RC; Cortical blindness following Hemophilus influenzae meningitis.; Ann Ophthalmol; 1985 Mar; 17(3); 193-194 Biglan AW, Milley JR, Brown DR, Reynolds JD; Blood oxygen, carbon dioxide and pH levels prior to diagnosis of retinopathy of prematurity.; J Pediatr Ophthalmol Strabismus; 1985; 22(2); 44-50 Reynolds JD, Hiles DA, Baker JD, Biglan AW, Walden PG; Six Muscle Surgery for Correction of V-Pattern Esotropia; Binocular Vision; 1985 Jan; 1(1); 27-34 Biglan AW, Brown DR, Reynolds JD, Milley JR; Risk factors associated with retrolental fibroplasia.; Ophthalmology; 1984 Dec; 91(12); 1504-1511 Reynolds JD, Biglan AW, Hiles DA; Congenital superior oblique palsy in infants.; Arch Ophthalmol; 1984 Oct; 102(10); 1503-1505 Reynolds JD, Hiles DA, Golden WL, Zhang Y; Ocular Abnormalities in Terminal Deletion of the Long Arm of Chromosome Seven; J Ped Ophthalmol & Strabismus; 1984 Jan; 21; 28-32 Reynolds JD, Hiles DA; Single Lateral Rectus Muscle Recession for Small Angle Exotropia, in Reinecke, RD ed: STRABISMUS II; Grune & Stratton; 1984 Jan; Reynolds JD, Hiles DA; The Posterior Fixation Suture for Abnormal Distance/Near Esotropia, in Reinecke, RD ed: STRABISMUS II; Grune & Stratton; 1984 Jan; Reynolds JD, Hiles DA, Johnson BL, Biglan AW; Hyperplastic Persistent Pupillary Membrane - Surgical Management; J Ped Ophthamol & Strabismus; 1983 Jan; 20; 149-152 Reynolds JD, Hiles DA; Persistent Hyperplastic; Trans PA Acad Ophthalmol Otolaryngol; 1983 Jan; 36; 31-36 Hiles, DA Johnson, BL Biglan, AW REYNOLDS JD; Intraocular Lens in a Child; American Journal of Ophthalmology; 1982 Jan; 93; 289-293 Reynolds JD, Hiles DA; Posterior Fixation Suture; Am Orthoptic J; 1982 Jan; 32; 81-86

GRANTS

P.I. “LIGHT-ROP Multicenter Trial - Project Director NIH Grant No. 1UI0EY09953-01A2 - 04/01/95 – 04/01/99; Total $1,657,754 in direct expenses Year one $391,122.00 Year two $341,431.00 Year three $595,512 Year four $329,689 Co-PI “Early Treatment for Retinopathy of Prematurity (ETROP)” NIH Grant No 1U1OEY1247101; total $147,454 in direct expenses 06/30/00 – 09/29/00 - $8,507 09/30/00 – 09/29/01 - $46,508 09/30/01 – 09/29/02 - $47,860 09/30/02 – 09/29/03 - $28,015 09/30/03 – 09/29/04 - $16,564 Co-P.I. “CRYO-ROP Phase III - Randomized Infants” NIH.Grant No. U01-EY06354-01; Total $25,926 in direct expenses 06/01/93 - 05/31/94 - $8,142.00 06/01/94 - 05/31/95 - $8,631.00 06/01/95 - 05/31/96 - $9,153.00 Co-P.I. “Multicenter Trial of Cryotherapy for Retinopathy of Prematurity”. Natural History Clinical Center 1989 - 1994. NIH Grant No. U01-EY06354-05; Total $280,155.00 in direct expenses. Funding site Children’s Hospital of Buffalo 06/01/89 - 05/31/90 - $52,350.00 06/01/90 - 05/31/91 - $56,492.00 06/01/91 - 05/31/92 - $58,752.00 06/01/92 - 05/31/93 - $61,103.00 06/01/93 - 05/31/94 - $51,458.00 P.I. “Fetal Ocular Blood Flow and Retinal Anti-oxidant Physiology Under Hyperbaric Conditions”. American Legion Auxiliary - State President’s Project. Funding amount- $9,000.00 1990 P.I. - “Feasibility and Outcome of Goggle Light Reduction in Low Birth Weight Premature Infants”. Women and Children’s Health Research Foundation. Funding amount 14,000.00 1991