• Primary Faculty Profiles
• Adjunct Faculty Profiles
• Crane, John, M.D., Ph.D., Assistant Professor
• Genco, Robert, Ph.D., Distinguished Professor
• Gill, Steven, Ph.D.
• Knight, Paul, M.D. and Ph.D., Professor
• Lesse, Alan, Ph.D., Professor
• Murphy, Timothy, Ph.D., Professor
• O'Brian, Mark, Ph.D., Professor
• Rittenhouse-Olson, Kate, Ph.D., Associate Professor
• Russo, Thomas, Ph.D., Assistant Professor
• Departmental Publications
• Career Opportunities
• The Witebsky Center
• Seminars

Faculty and Research

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Education:

1973, Ph.D., Pennsylvania State University, Hershey, PA
1973, M.D., Pennsylvania State University, Hershey, PA
1969, Bachelor of Science, University of Nebraska, Lincoln, NB

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Research Interests:

We examine inflammatory mechanisms involved in the pathogenesis of non-infectious (gastric aspiration, lung contusion, asthma), as well as viral (influenza) and bacterial acute lung injuries. We are particularly interested in pulmonary insults that have a strong clinical association, i.e., secondary bacterial pneumonia following gastric aspiration or influenza. In this regard, we are also involved in nanoparticle cell targeting as a therapeutic modality for a variety of insults in collaboration with the CDC. Additionally, we also have developed strong collaborations based on our expertise regarding mechanisms of inflammatory injury to study the pathogenesis of non-pulmonary inflammatory injuries (CNS, liver, cochlea).

Relevant references:

1.    Knight PR, Sreekumar A, Siddiqui J, Laxman B, Copeland S, Chinnaiyan A, Remick DG.  Development of a sensitive microarray immunoassay and comparison to standard ELISA for cytokine analysis.  Shock 21:26-30, 2004.

2.   Davidson BA, Stewart CC, Russo TA, Chess PR, Notter, RH, Knight PR. Discrimination of Resident and Infiltrated Alveolar Macrophages by Flow Cytometry in Influenza A Virus-Infected Mice.  Experimental Lung Research, 31:323-339, 2005.

3.   Segal BH, Davidson BA, Hutson AD, Russo TA, Holm BA, Mullan B, Habitzruther M, Holland SM, Knight PR. Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. AJP-Lung, 292(3):L760-8, 2007.

4.   Spengler RN, Sud R, Knight PR, Ignatowski TA. Antinociception mediated by alpha2-adrenergic activation involves increasing TNF· expression and restoring TNF· and alpha2-adrenergic inhibition of norepinephrine release. Neuropharmacology, 52(2):576-89, 2007.

5.   Russo TA, Davidson BA, Beanan JM, Olson R, Holm BA, Notter RH, Knight PR 3rd. Capsule and O-antigen from an extraintestinal isolate of Escherichia coli modulate cytokine levels in rat macrophages in vitro and in a rat model of pneumonia. Exp Lung Res. 33(7):337-56, 2007.

6.   Sands MF, Ohtake  PJ, Mahajan SD, Takyar SS, Fang YV, Blume JW, Mullan, BA, Sykes DE, Aalinkeel R, Lachina S, Knight PR, Schwartz SA. Tissue Inhibitor of Metalloproteinase-1 Modulates Allergic Lung Inflammation in Murine Asthma. Accepted for publication, Clinical Immunology, 2008