|
Major Areas of
Research
- Human Physicology:
pathophysiology and
clinical asssessment
of arterial stiffness
and systolic hypertension,
mechanisms of stress
responses and vasoractivity
- Clinical
Trials:
Antihypertensive
and cardiovascular
drug development
with emphasis
on macrovascular
disease indicators.
- Basic Investigation (in
collaboration with
Dr. Knight): sympathetic
neurinal signal transduction.
Our studies
in the field of hypertension
have included basic investigation
and applied pharmaceutical
approaches to investigate
the characteristics of
individual and population-based
responses to drug therapy,
especially why individuals
respond differentially
to specific drugs.
Specific
focus areas of interest
have included sympathetic
neuronal signaling systems
and clinicalphysiology
of the sympathetic nervous
system. Vascular research
themes include exaggerated
vasoreactivity and the
assessment of arterial
stiffness and other biophysical
changes related to aging
and hypertension. Other
long-term interests involve
clinical trials in hypertension
and cardiovascular diseases
and clinical outcomes
in cardiovascular diseases.
Current Research
Strengths
Program faculty have particular
strengths in the featured
subdisciplines of
- Autonomic-cardiovascular-hypertension
(cellular and integrative)
- Antibiotics-infectious
diseases
- Pharmacologic data
analysis and outcomes
research
- Drug development
sciences
Current Research
Projects
The scope of research
projects in both the
Department of Medicine
and Clinical Pharmacokinetics
Laboratory, Millard Fillmore
Health System, is wide-ranging.
Ongoing projects by core
faculty and fellows include
but are not limited to:
- Classical research
in drug development,
including studies
of pharmacokinetics
and pharmacodynamics,
particularly in cardiovascular,
antibiotic, and anti-diabetic
drugs
- Outcomes research
using novel modeling
and drug monitoring
techniques
- Local and systemic
pharmacodynamic effects
of vasoactive drugs
- Cardiovascular pharmacokinetics
and pharmacodynamics,
and cardiovascular
reactivity
- Antimicrobial pharmacokinetics
and pharmacodynamics
and sepsis research
- Pharmacokinetic and
pharmacodynamic modeling
- Renal and hepatic
pharmacokinetic studies
- pH-dependent drug
absorption studies
- Development of biobehavioral
techniques that are
applicable to testing
pharmaceutical agents
(e.g., cardiovascular
effects of mental
stress)
- Cellular physiology.-
physiological and
pharmacological studies
in isolated cardiomyocytes,
vascular smooth muscle
cells and adrenergic
neurons
- Pharmacology of L-type
calcium channels
in cultured neurons
and vascular smooth
muscle
- Clinical trials of
cardiovascular, metabolic,
anti-infective, and
antiinflammatory
drugs (Phases I-IV)
|
