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Center for Research and Education in Special Environments

 
 

 

Claes E.G. Lundgren  

Professor of Physiology and Biophysics

University of Lund School of Medicine, Lund, Sweden  M.D.  1959  Medicine
University of Lund                                                        Ph. D. 1967  Physiology

Professional Experience:

1951-77 Junior Instructor, Assistant Professor, Associate Professor pf Physiology,    Dept. of Physiol, Univ of Lund, Research Physician with Swedish Board of Aviation & Naval Medicine and Swedish Medical Research Council

1974-75 Visiting Associate Professor of Physiology, SUNY at Buffalo, NY

1976-99 Professor of Physiology, SUNY at Buffalo, NY

1999-     Professor of Physiology and Biophysics, SUNY at Buffalo, NY

1977- Director, Center for Research and Education in Special Environments (CRESE), SUNY at Buffalo, NY

Consultanships, Services & Editorial Boards (From list of over 30 items):

1974-79 Member, Editorial Board, Undersea Biomedical Research

1990-     Member, Review Board, European Journal of Applied Physiology and Occupational Physiology

Honors and Awards:

1982 Stover-Link Award, Undersea Medical Society

1994-98 Editor (with Dr. John Miller) of "The Lung at Depth" in the series "Lung Biology in Health and Disease" Marcel Dekker, by invitation from Dr. C. Lenfant, Head Editor.

1997 The Albert Behnke Jr. Award, Undersea and Hyperbaric Medical Society

2000 First Place Niagara Frontier Inventor of the Year Award in Science

2000 Invited Speaker, Symposium on "Current Advances in Biophotonics and Nanomedicine", held October 19-21, 2000 in Buffalo, NY

Professional Society Memberships:

Aerospace Medical Assoc, American Physiological Soc, European Undersea Biomedical Soc, Swedish Inventors, Assoc, Undersea and Hyperbaric Medical Society. 

Patents:

Holds (with co-inventors) more than 120 patents pertaining to, among other areas, human engineering (breathing gear for divers) and the pharmaceutical fields (NicoretteR for smoking withdrawal; Erythrocyte substitute comprised of intravascular microbubbles ).

CURRENT FUNDING:

  1. Continued development and testing of a membrane-based CO2 eliminator for divers' breathing gear, USN Office of Naval Research, Contract #NO00149710266 (150-1254A), 2/1/97-10/31/01 ($967,308)

  2. Volume-stabilized intravascular microbubbles for circulatory transport of oxygen and carbon dioxide, US Army Medical Res. Acquisition Activity, Contract #DAMD170010514 (150-1828A), 5/1/00-9/3/01 ($276,869)

  3. Respiratory muscle training in VSW Divers, Coastal Systems Station, Contract #N6133101CO016 (101602220726 1) 3/21/01-3/20/02 ($88,411)

  4. Enhancement of decompression by negative pressure breathing, Coastal Systems Station, Contract #N0463A01RO22024 (101596920840 1) 3/22/01-3/21/02 ($100,000)

  5. Treatment of hemorrhagic shock, in a porcine model, with oxygen carrying intravascular microbubbles, US Army Medical Res. Acquisition Activity, Contract # pending, 8/1/01-7/31/02 ($1,199,970)

BIBLIOGRAPHY:

Over 120 Scientific book chapters and articles in international, critically refereed journals, primarily in the area of environmental physiology

SELECTED PUBLICATIONS:

  1. Shastri, KA., Logue, GL, Lundgren, CEG, Logue, CJ and Suggs, DF. Diving decompression fails to activate complement. Undersea & Hyperbaric Medicine 24(2):51-57,1997.

  2. Ferrigno, M., Ferretti, G., Ellis, A., Warkander, D.E., Costa, M., Cerretelli, P. and Lundgren, C.E.G. Cardiovascular changes during deep breath-hold dives in a pressure chamber. J. Appl. Physiol 83: 1282-1290, 1997.

  3. Kawai, Y., Puma, S.C., Hargens, A.R., Murthy, G., Warkander, D. and Lundgren, C.E.G. Cerebral blood flow velocity and fluid volume decrease during + Gz acceleration”. J Gravitational Physiology 4(3):31-34, 1997

  4. Warkander, D.E., and Lundgren, C.E.G. Dead space and acceptable breathing resistance in divers' breathing gear; A Review of Experiments at CRESE. IN: Proceedings of the 14th Meeting of the United States -Japan Cooperative Program in Natural Resources (UJNR). Panel on Diving Physiology, held in Panama City, FL, September 16-17, 1997.

  5. Ferrigno, M., Lundgren, CEG. Human Breath-Hold Diving. Chap. 13. In: The Lung at Depth in the series Lung Biology in Health and Disease. Lundgren, CEG, Miller, J. (eds). New York: Marcel Dekker Publishers. 132:529-585, 1999.

  6. Lundgren, CEG. Immersion Effects. Chap. 3. In: The Lung at Depth in the series Lung Biology in Health and Disease. Lundgren, CEG, Miller, J. (eds). New York: Marcel Dekker Publishers. 132:91-128,1999.

  7. Lundgren, Claes E. Does the cardiovascular diving response have a protective effect in near-drowning incidents? In: Near Drowning. Forty-seventh Workshop of the Undersea & Hyperbaric Medical Society held at Marriott Casa Magna Cancun, Mexico, 22 June 1997. C.W. Dueker, S.D. Brown (Chairmen). pp 11-14, 1999.

Selected Abstracts:

  1. Lundgren C, Bergoe G, Olszowka A, Logue G, Tyssebotn I. Intravascular microbubbles used for successful treatment of right-to-left circulatory shunts in the lung. Presented at the 1999 UHMS Annual Meeting, held at Westin Copley Place, Boston, June 26-30, 1999. Undersea & Hyperbaric Medicine 26(suppl):98, 1999.

  2. Warkander D, Leddy J, Boutellier U, Lundgren CEG. Respiratory muscle training improves divers' submaximal cycle endurance. Presented at the 1999 UHMS Annual Meeting, held at Westin Copley Place, Boston, MA, June 26-30, 1999. Undersea & Hyperbaric Medicine 26(suppl):69, 1999.

  3. Leddy JJ, Moalem J, Roberts A, Lundgren CEG. Pulmonary mechanics in exercise-induced asthma during water immersion. Presented at the 1999 UHMS Annual Meeting, held at the Westin Copley Place, Boston, MA, June 26-30, 1999. Undersea & Hyperbaric Medicine 26(suppl):113, 1999.

  4. Curry TB and Lundgren CEG. Enhancement of nitrogen elimination by negative pressure breathing. Presented at the 2000 UHMS Annual Meeting, held at Stockholm City Conference Center "Folkets Hus", Stockholm, Sweden, June 18-22,2000. Undersea & Hyperbaric Medicine 27(suppl):105, 2000.

  5. Chang LP and Lundgren CEG. Increased CO2 wash-out during immersion. Presented at the 2000 UHMS Annual Meeting, held at Stockholm City Conference Center "Folkets Hus", Stockholm, Sweden, June 18-22, 2000. Undersea & Hyperbaric Medicine 27(suppl): 129,2000.

  6. Krauza ML and Lundgren CEG. The effects of body position on inspiratory air flow in divers. Presented at the 2000 UHMS Annual Meeting, held at Stockholm City Conference Center "Folkets Hus", Stockholm, Sweden, June 18-22, 2000. Undersea & Hyperbaric Medicine 27(suppl):127, 2000.

  7. Leddy J, Warkander DE, Boutellier U, Lundgren CEG. Respiratory muscle training improves submaximal exercise endurance at altitude. Presented at the 2000 UHMS Annual Meeting, held at Stockholm City Conference Center "Folkets Hus", Stockholm, Sweden, June 18-22,2000. Undersea & Hyperbaric Medicine 27:161,2000.

  8. Warkander DE, Clarke JR, Lundgren CEG. A mathematical model of the respiratory mechanics and calculations of the work of breathing applied to the diver. Presented at the 2000 UHMS Annual Meeting, held at Stockholm City Conference Center "Folkets Hus", Stockholm, Sweden, June 18-22,2000. Undersea & Hyperbaric Medicine 27(suppl): 123,2000.

  9. Lundgren C., Bergoe G., and Tyssebotn I. Perfluorocarbon-stabilized intravascular microbubbles: an ultra-effective mode of oxygen delivery. Eighth International Symposium on Blood Substitutes, San Diego, California, November 9-11,2000.

  10. Tyssebotn I., Bergoe G., and Lundgren C. Intravascular perfluorocarbon-stabilized microbubbles for treatment of hypoxemia due to an experimental intrapulmonary shunt. Eighth International Symposium on Blood Substitutes, San Diego, California, November 9-11,2000.

  11. Tyssebotn I., Bergoe G.W. and Lundgren C. Volume-stabilized intravascular microbubbles provide vital oxygenation in hemoglobin depleted pigs during "air breathing". Undersea and Hyperbaric Medical Society Annual Scientific Meeting, San Antonio, Texas, June 13-16,2001.

  12. Lundgren C., Bergoe G.W. and Tyssebotn I. Tissue denitrogenation by oxygen breathing is enhanced by perfluorocarbon- stabilized intravascular microbubbles. Undersea and Hyperbaric Medical Society Annual Scientific Meeting, San Antonio, Texas, June 13-16,2001.

  13. Tyssebotn I., Bergoe G. W. and Lundgren, C. Extremely low doses of dodecafluoropentane emulsion sustain life and function in erythrocyte depleted animals. Accepted for publication at the International Society on Oxygen Transport to Tissue 29th Annual Meeting, Philadelphia, PA, August 11-15,2001.

  14. Ferrigno, M., Lundgren, C.E. Breath-Hold Diving. In: The Physiology and Medicine of Diving. Brubakk, A., Neuman, T. (eds). London: W. B. Saunders Company Ltd Publishers (accepted for publication).

  15. Warkander, D.E., Nagasawa, G.K., Lundgren, C.E.G. Effects of inspiratory and expiratory resistance in divers' breathing apparatus. Undersea and Hyperbaric Medicine (accepted for publication).