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Kate Rittenhouse-Olson, Ph.D., SI(ASCP)CM
Research Interests:
Dr. Rittenhouse-Olson's research research for the last 22 years has focused on
carbohydrate antigens that are important in cancer and in infectious disease (bacterial, viruses and parasites).
These structures play important roles in the growth, adhesion and spread of cancer cells and bacteria and viruses.
Immune responses to these structures can therefore be an effective mechanism to decrease disease. The anti-carbohydrate
immune response is usually T cell independent, more difficult to develop and less in magnitude than the immune response
to proteins. Her long-term goals involve using information obtained about carbohydrates of related structures to manipulate
the anti-carbohydrate immune response to improve clinical outcome. This work has involved use of synthetic oligosaccharides
conjugated to bovine serum albumin as antigens, the use of structurally related synthetic oligosaccharides in inhibition
studies, the use of antibody to carbohydrates in immunotherapy and immunolocalization of cancer, the use of genetic
analysis of genes related to carbohydrate synthesis and adhesion, bacterial vaccine stability assays and bacteria rapid
diagnosis assay development. The immunochemical aspects of this work were performed to determine the immunodominant
regions of the sugars and the effects of small structural changes in the inhibitory oligosaccharides on the immunologic
reaction.
She has been involved in research concerning the immune response to carbohydrate antigens since 1984, through experience
gained while a post-doctoral fellow at Roswell Park Cancer Institute (RPCI), gaining clinical diagnostic experience with
Dr. T. Ming Chu, (the discoverer of Prostate Specific Antigen for diagnosis) and then carbohydrate experience with
Dr. Khushi Matta (Carbohydrate synthetic chemist). Since that time, I have been involved in the development of monoclonal
and polyclonal antibodies to defined saccharides as diagnostic markers or as vaccine candidates in both bacterial and cancer
research.
Her laboratory, RPCI based for the first 9 years, and now at UB for the last 13 years, has had an emphasis on tumor
associated carbohydrate antigens, and recently has been involved in 2 patent applications, “Use of anti-TF antibody to
block metastasis of TF- antigen bearing tumors” (K R Olson, principle inventor of JAA-F11 monoclonal antibody), and
“Carbohydrate Antigen-Nanoparticle Conjugates and Methods for Inhibiting Metastasis in Cancer” (K R Olson, co-inventor).
Thomsen-Friedenreich antigen (TF-Ag) is a tumor associated antigen that is exposed in many types of carcinoma cells
including breast, prostate, colon, and bladder.
Recent Publications:
R. Chaturvedi, J. Yan, J. Heimburg, S. Koury, M. Sajjad, and K. Rittenhouse-Olson.
Immuno-PET and Biodistribution using Iodine-124 labeled anti- Thomsen-Friedenreich-Antigen
Monoclonal Antibody JAA-F11. Applied Radiation and Isotopes. 2007.
http://www.sciencedirect.com/dx.doi.org/10.1016/j.apradiso.2007.07.029
Jamie Heimburg, Jun Yan, Susan Morey, Olga V. Glinskii, Virginia H. Huxley,
Vladislav V. Glinsky, Linda Wild, Robert Klick, Rene Roy and Kate Rittenhouse-Olson.
Therapeutic Potential of a Monoclonal Anti-T-Ag Antibody for Breast Carcinoma.
Neoplasia feature article, cover photo volume 8 :11 939-948. (2007)
Jason Catania, Barbara McGarrigle, Kate Rittenhouse-Olson, and James Olson.
Induction of CYP2B and CYP2E1 in Precision-Cut Rat Liver Slices Cultured in Defined Medium
Toxicology in Vitro. Vol. 21, No. 1, pages 109-115 (2007)
O. Kurtenkov, K. Klaamas, K. Rittenhouse-Olson L. Vahter, B. Sergejev, L. Miljukhina, L. Shljapnikova .
IgG Immune response to Tumor-Associated Carbohydrate Antigens (TF, Tn, alphaGal) in Patients
with Breast Cancer: Impact of Neoadjuvant Chemotherapy and Relation to the Survival.
Experimental Oncology 27, No 5 136-140. 2005
Li, G., Pandey, S.K. Pandey,
Dobhal,M.P., Mehat, R., Chen, Y., Gryshuk, A., Rittenhouse-Olson, K., Oseroff,
A., and Pandey, R.K. Functionalization of OEP-Based
Benzocholrins to Develop Galectin-Specific Photosensitizers for Photodynamic
Therapy. J. Org. Chem. 69(1); 158-172. 2004.
Sally A.Quataert, Kate Rittenhouse-Olson, Carol S. Kirch, Branda Hu, Shelley
Secor, Nancy Strong, and Dace V. Madore. Assignment of Weight-Based Antibody
Units for 13 Serotypes to a Human Anti-pneumococcal Standard Reference Serum,
Lot 89-S. Accepted Clinical and Diagnostic
Immunology August 2004.
Dziegelewski, M,, Simich, J.P., Rittenhouse-Olson, K. Use of a Y Chromosome
Probe as an Aid in the Forensic Proof of Sexual Assault. J. Forensic Science.
47: 3:601-604, 2002.
Kurtenkov,O., Klaamas,K., Rittenhouse-Olson, K., Brjalin,V., Miljukhina, L.,
Shljapnikova L., and L Engstrand. Expression of tumor-associated Thomsen-Friedenreich
(T) antigen in Helicobacter pylori and modulation of T Ag specific immune
response in infected individuals. Immunological Investigations 31:191-204, 2002.
Siebert, H-C, Lu,S-Y., Frank, M., Kramer, J., Wechselberger, R., Joosten, J.,
Andre, S., Rittenhouse-Olson, K., Roy, R., von der Leith, C-W., Kaptein, R.,
Vliggentthart, J.F.G., Heck, A.J. and H.-J. Gabius. Analysis of
Protein-Carbohydrate (T-F) Interaction at the Lower Size Limit of the Protein
Part (15-Mer Peptide) by NMR Spectroscopy, Electrospray Ionization Mass
Spectroscopy and Molecular Modeling. Biochemistry. 41(30):9707-17, 2002.
Delles, A. M., Rittenhouse-Olson, K., Morgan, J., and Oseroff, A. R. A simple
method for the purification of human peripheral blood antigen presenting cells (dendritic
cells, monocytes/macrophages, and B lymphocytes) Immunologic Investigations
31:233-245, 2002.
INVITED EDUCATIONAL ARTICLES (PEER REVIEWED):
Rittenhouse-Olson, K.. Generalist No G- 2003 Immediate Hypersensitivity. Section editor: Peggy Simpson Tech Sample ASCP. For CMLE credits.
Rittenhouse-Olson, K.. . Clinical Immunology No CI- 1 2003 Lyme Disease. Section editor: Linda Miller. Tech Sample ASCP. For CMLE credits.
Jones, A., Heimburg, J., and Rittenhouse-Olson, K.. Microbiology No MB-4 2003 Group B Streptococcus Streptococcus agalactiae. Section editor: Susan Sharp. Tech Sample ASCP. For CMLE credits.
Rittenhouse-Olson, K.. Generalist G- 2004 HIV testing and confidentiality. Section editor: P. Simpson Tech Sample ASCP. For CMLE credits.
Rittenhouse-Olson, K.. Clinical Immunology 2005 Acute anaphylaxis after fresh frozen plasma transfusion in an IgA deficient patient. Tech Sample ASCP. For CMLE credits.
Rittenhouse-Olson, K.. Education and Management- 2005. You’ve Got Ninety Seconds, Show Them All about It. Section editor: K. Myers Tech Sample ASCP. For CMLE credits.
Rittenhouse-Olson, K. Opt-out screening for HIV infection. LabQ 2008 in press. ASCP. For CMLE credits.
INVITED BOOK CHAPTERS AND REVIEWS:
Rittenhouse-Olson, K. Tumor Immunology, In Clinical Immunology and Serology by Christine Stevens. F.A. Davis. N.Y., N.Y.2003.
Heimburg, Jamie, and Rittenhouse-Olson, K. Development and Characterization of Antibodies to Carbohydrate Antigens. In Methods in Molecular Biology. 2008. editors Nicolle Packer & Niclas Karlsson.
Rittenhouse-Olson, K. Future Perspective article. JAA-F11: Extending the life of mice with breast cancer. In p.923-927. Expert Opinions in Biological Therapy 7 (7) 2007.
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