Department of Biochemistry
School of Medicine & Biomedical Sciences

Undergraduate Program


BIOCHEMISTRY

FALL 2007
Department of Biochemistry
School of Medicine and Biomedical Sciences
140 Farber Hall, 3435 Main St.
Buffalo, NY 14214-3000
(716) 829-2727
Fax: (716) 829-2725
Web: www.smbs.buffalo.edu/bch
Kenneth Blumenthal, Chair
Gail R. Willsky, Director of Undergraduate Education
Beth O'Brocta, Assistant to the Chairman eobrocta@buffalo.edu

Biochemistry addresses the chemical principles that underlie biological processes. The course of study in biochemistry emphasizes macromolecular structure and function, control of gene expression and metabolic regulation as they relate to basic and biomedical science. The strength of the program lies in the extensive research experience in the laboratories of the faculty. Graduates are prepared to enter medical, dental, or graduate school, or to go into occupations in academic, industrial, medical, or governmental settings. The course requirements of the first two years are common to a number of science majors and allow the student considerable flexibility at the end of the sophomore year. There is no minor available in biochemistry.

Interested students should contact the director of undergraduate studies during the second semester of the sophomore year. Applicants should bring a copy of a current UB DARS report directly to the administrative assistant in the Department of Biochemistry. Students are admitted to full standing in the department after successful completion of their first two years.

Students are encouraged to apply in their 2nd semester of the 2nd year of study OR when 60 credit hours are completed.

Please print and complete the application (click HERE for printable form) and mail to our department address, Attention:  Beth O'Brocta.

Biochemistry Force Registration Form.

401 Introduction to Research (1) (F)
Prerequisite: accepted biochemistry major
Designed for accepted students about to start the upper-division biochemistry program. Meets once per week for one hour, with scheduled library workshops. The course includes critically reading a scientific paper, introduces library skills needed to do research, and correlates basic biochemistry knowledge with ongoing research programs in the biochemistry department. Students use these presentations to help them arrange for 2 credit hours of BCH498 for the following semester. LEC (Pass/Fail)

403 Biochemical Principles (4) (F)
Prerequisites: BIO200; CHE202
One semester general biochemistry course for science majors and students of pharmacy. Covers protein and membrane structure and function, metabolism, and nucleic acid structure and molecular biology. LEC

404 Advanced Topics in Biochemistry (3) (Sp)
Prerequisite: accepted biochemistry major; BCH401, BCH403
Covers five areas of biochemistry beyond the basic survey course BCH403. Each subject area is covered in three weeks; one week with lecture material, one week with detailed faculty led discussion or reviews and literature papers, and one week of presentation of papers by students. SEM

405 Research Topics in Biochemistry (3) (F)
Prerequisite: accepted biochemistry major; BCH401, BCH403, BCH404
Focuses on learning cutting-edge biochemistry by reading, analyzing, and discussing research papers. Topics emphasize the molecular and mechanistic aspects of signal transduction in growth, differentiation, development and cancer; and signaling in response to hormones to the nervous system. SEM

407 Research Presentations (1) (Sp)
Prerequisite: senior standing in biochemistry
Students attend one research seminar per week involving biochemistry and write a two- to three-page report of that seminar. If the student obtains a paper by the seminar speaker and incorporates that into the report, it takes the place of one seminar. SEM

408 Gene Expression (2) (Sp)
Prerequisite: permission of instructor
Designed to familiarize students with up-to-date concepts in eukaryotic gene expression. Through a classroom discussion of selected papers, students are introduced to current issues in gene transcription, mRNA processing, and their regulation. Classroom learning is augmented with detailed problem sets. SEM

498 Undergraduate Research Participation in Biochemistry (1-8) (F; Sp)*

Prerequisite: permission of instructor
Under the direction of faculty, original investigation project involving library and lab work. Open to majors as a senior research project. TUT

499 Independent Study (1-6) (F; Sp)
For students having specific academic interests or objectives; department faculty sponsor required before preregistration. TUT

*BCH 498 - Undergraduate Research in Biochemistry: Biochemistry majors are required to take 8 credit hours of undergraduate research. Students usually start with 2 credits in the 2nd semester of their junior year and then take 3 credits each semester in their senior year. Students who are participating in a Summer Fellowship Program, such as the Hughes Program, can petition to have some of their BCH 498 credits waived. Those students will still be required to have 82credit hours of science and math courses. Students may identify a research mentor in Biochemistry or any faculty in the School of Medicine and Biomedical Sciences (BCH 498 MED) or Roswell Park Cancer Institute (BCH 498 RPCI). Registration for this is through the departmental office - force registration only. Each credit hour registered for constitutes 3 - 4 hours working on a research project.

Poster Requirement: Students are also required to make a poster presentation of their work as part of their research experience (BCH498). It is the student's responsibility to have their poster venue approved by the Director of Undergraduate Studies and to submit documentation to the Director that they have satisfied this part of their degree requirement. Possible poster presentation venues include the Sigma Xi Participation, BCH Research Day and the Celebration of Academic Excellence.

Departmental Honors: To receive Departmental Honors students must have the appropriate overall GPA for Latin Honors. Students must also prepare a research paper on their BCH 498 research project. The format for this paper consists of an Abstract ( one page maximum); Introduction, Methods, Results, and Discussion (minimum 5 pages, double spaced); Data - Figures with Figure Legend and/or Tables; and a Reference Section with a minimum of 5 papers with authors, year, article title, journal, volume and inclusive page numbers.

ACCEPTANCE CRITERIA
Applications accepted after three semesters or 60 credit hours
Minimum GPA of 2.0 overall
Minimum GPA of 3.0 in science courses listed in first and second year

PRE-REQUISITE COURSES
Two of the following three BIO Courses:
o BIO200 Evolutionary Biology
o BIO201 Cell Biology
o BIO205 Fundamentals of Biological Chemistry
BIO215 Fundamentals of Biological Chemistry Laboratory
CHE101 General Chemistry
CHE102 General Chemistry
CHE201 Organic Chemistry
CHE202 Organic Chemistry
MTH141 College Calculus I
MTH142 College Calculus II
PHY107 General Physics I
PHY108 General Physics II
PHY158 General Physics II Lab

A
REQUIRED COURSES IN BIOCHEMISTRY AND UPPER LEVEL SCIENCE
(36-37 CREDITS)
BCH401 (1) Introduction to Research - Fall semester, junior year
BCH403 (4) Biochemical Principles - Fall semester, junior year
BCH404 (3) Adv. Topics in Biochemistry - Spring semester, junior year
CHE319 (3) Physical Chemistry OR CHE349 Phys. Chem. for Life Sciences - Fall semester, senior year
BCH405 (3) Research Topics in Biochemistry, Fall semester, senior year
BCH407 (1) Research Seminars - Spring semester, senior year
BCH498 (8) Undergraduate Research - should begin with 2 credits in the 2nd semester of the junior year.

B. RESTRICTED CHEMISTRY
ELECTIVES One of the following courses is required (3-4 credits)

CHE321 (3) Inorganic Chemistry (Fall) CHE320 (3) Physical Chemistry (Spring)
CHE413 (4) Instrumental Analysis (Fall) CHE312 (3) Chem. of Biological Systems (Spring)
MCH311 (3) Chemistry of Drug Action (Fall) CHE455 (3) Synthetic Organic Chemistry (Spring)
MCH401 (3) Principles of Med. Chem. (Fall)  

C. UPPER LEVEL SCIENCE AND/OR MATH: An additional 10 credit hours in upper level science and/or math is required for a total of 82 -84 credit hours.

Upper Level Science Courses: Biochemistry majors are required to take 10 credit hours of Upper Level Science (300 or above). Math 241 and selected 200 level Engineering courses may be applied to this requirement with approval by the Director. At least 6 credit hours must come from Biological Sciences, Health Science or Chemical Science. All electives must be pre-approved by the UG Director.

The following are a list of approved electives that will fulfill this requirement:
APY 345, 346
BIO 302, 309, 312, 319, 367, 401, 402, 404, 406, 410, 415, 417, 448, 456, 468
BPH 303, 403, 405
*CHE 320, 321, 322, 412, 413, 423, 455 470
EAS 207
*MCH 311, 401, 403
MIC 301, 401, 412
MTH 241, 306
PGY 300, 451, 452, 412, 427
PHY 207, 208, 301, 403
STA 427
* Courses used to satisfy the Advanced Chemistry elective are not eligible for inclusion in the required 10 credit hour electives.

Sections (A), (B), (C) and a Poster Presentation are required for Degree Conferral.

RECOMMENDED SEQUENCE OF MAJOR REQUIREMENTS
First Year

MTH141 College Calculus I (F)
CHE101 General Chemistry (F)
BIO200 Evolutionary Biology (F)
MTH142 College Calculus II (Sp)
CHE102 General Chemistry (Sp)
BIO201 Cell Biology (Sp) and/or

Second Year
CHE201 Organic Chemistry (F)
PHY107 General Physics I (F)
One elective (F)
CHE202 Organic Chemistry (Sp)
PHY108 General Physics II (Sp)
PHY158 General Physics II Lab (Sp)
BIO205 Fundamentals of Biological Chemistry
BIO215 Fundamentals of Biological Chemistry Laboratory (Sp)

Third Year**
BCH401 Introduction to Research (F)
BCH403 Biochemical Principles (F)
BCH404 Advanced Topics in Biochemistry (Sp)
BCH498 Undergraduate Research Participation in Biochemistry (Sp)
One/two 300/400-level science/math elective (F)(Sp)***
(CHE319/349 may be taken in the third year)

Fourth Year**
CHE319/349 Physical Chemistry (F)
BCH498 Undergraduate Research Participation in Biochemistry (F) (Sp)
One/two 300/400-level science/math elective (F)(Sp)***
BCH405 Research Topics in Biochemistry (F)
BCH407 Research Presentations (Sp)

**Third or fourth year students must take one class from the following courses: CHE321, CHE413, MCH401, MCH311, CHE320 or CHE455.

*** STUDENTS ARE REQUIRED TO TAKE 10 CREDIT HOURS OF UPPER LEVEL DIDACTIC SCIENCE ELECTIVES APPROVED BY THE DEPARTMENT. 4 CREDIT HOURS OF MATHEMATICS BEYOND MTH142 MAY BE INCLUDED.

Summary
Total required credit hours in biochemistry (includes 8 credits of BCH498) and upper-level science  36-37
Total credit hours in science and math (all levels)  82-84

Career Choices:   Agronomist, Food & Drug Analyst, Biochemist, Food Technologist, Chemical Engineer, Geneticist, Chemist, Industrial Health Engineer, Consumer Protection, Nutritionist, Dietitian Patent Examiner, Educator, Sales Representative, Pharmaceutical, Environmentalist.

Recent graduates in Biochemistry have been employed in the following ways: Most go on to medical or graduate school. Recent grads have jobs as technicians in academia and industry.

Transfer Students:

Special admissions criteria: Contact Departmental office to arrange an interview.
Is preference given to UB students? No
Other advice for transfer students: We require 82 credit hours of science and math.
Colleges which have transfer agreements or 3/2 programs with Biochemistry: N/A
Colleges which have good feeder programs for this department: N/A

Combined courses of study:

Official joint majors with Biochemistry: N/A
Minors which complement a Biochemistry major: Chemistry, Biology, Chemical Engineering
Majors which benefit from a Biochemistry minor: No minor is available in Biochemistry
Courses outside the major which could improve employment opportunities: N/A

The Classroom:

The typical class size for:
Freshman/intro level courses is: N/A
Sophomore/intermed. level courses is: N/A
Upper level/advanced courses is: 15-30

In the Biochemistry Department, what do student teaching assistants (TA's) do?

TA's assist in lab and survey courses.

Post-Baccalaureate Opportunities:

The Biochemistry Department at UB offers these graduate degrees: M.A. and Ph.D.

The department does have a formal system for tracking graduates of its graduate programs. The department estimates that:

80 percent of its graduates go on to graduate or professional school
20 percent of its graduates are offered related employment

Departmental Honors:

To receive Departmental Honors students must have the appropriate overall GPA for Latin Honors. Students must also prepare a research paper on their BCH 498 research project. The format for this paper consists of an Abstract ( one page maximum); Introduction, Methods, Results, and Discussion (minimum 5 pages, double spaced); Data - Figures with Figure Legend and/or Tables; and a Reference Section with a minimum of 5 papers with authors, year, article title, journal, volume and inclusive page numbers.

Awards:

John Moran Memorial Award: Presented to the graduating senior with the highest grade in BCH403.

White Memorial Award: Presented to the graduating senior with the highest overall GPA and acceptance into Medical School.

Outstanding Senior Award

Faculty Distinctions:

Research Career Development Awards have been presented by the National Institutes of Health to five professors in Biochemistry. Two faculty members have received the Siegel Teaching Award from the Medical School, and one of these is a Distinguished Teaching Professor. Many faculty members serve on national editorial boards and grant review panels.

Department Resources:

Student researchers have access to state-of-the-art facilities for Biochemistry and Molecular Biology projects. This equipment includes: protein and nucleic acid electrophoresis equipment, ultracentrifuges, scintillation and gamma counters, a densitometer, spectrophotometers, protein sequencing facilities, oligonucleotide synthesizer, polymerase chain reaction thermocyclers, computer stations for word processing and data analysis, an electron spin resonance spectrometer and a sophisticated nuclear magnetic resonance facility.

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