Department of Biochemistry
School of Medicine & Biomedical Sciences
Faculty
RICHARD M. GRONOSTAJSKI, Ph.D.
Professor
Click the link below for a description of Dr. Gronostajki's research on The Nuclear Factor I (NFI) family of transcription/replication proteins:
Wong, Y. W., C. Schulze, T. Streichert, R. M. Gronostajski, M. Schachner, and T. Tilling. Gene expression analysis of nuclear factor I-A (NFI-A)-deficient mice indicates delayed brain maturation. Genome Biol. 8 (2007) R72.
Wang, W., D. Mullikin-Kilpatrick, J. E. Crandall, R. M. Gronostajski, E. D. Litwack, and D. L. Kilpatrick. Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules. J. Neurosci. 27 (2007) 6115-27.
Lu, W., F. Quintero-Rivera, Y. Fan, F. S. Alkuraya, D. J. Donovan, Q. Xi, A. Turbe-Doan, Q. G. Li, C. G. Campbell, A. L. Shanske, E. H. Sherr, A. Ahmad, R. Peters, B. Rilliet, P. Parvex, A. G. Bassuk, D. J. Harris, H. Ferguson, C. Kelly, C. A. Walsh, R. M. Gronostajski, K. Devriendt, A. Higgins, A. H. Ligon, B. J. Quade, C. C. Morton, J. F. Gusella, and R. L. Maas. NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. PLoS Genet 3 (2007) e80.
Deneen, B., R. Ho, A. Lukaszewicz, C. J. Hochstim, R. M. Gronostajski, and D. J. Anderson. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron 52 (2006) 953-68.
Butz, N. V., R. M. Gronostajski and C. E. Campbell. T-box proteins differentially activate the expression of the endogenous interferon gamma gene versus transfected reporter genes in non-immune cells. Gene 377:130-9, 2006.
Lazakovitch, E., J. M. Kalb, R. Matsumoto, K. Hironoa, Y. Kohara, and R. M. Gronostajski. nfi-1 affects behavior and life-span in C. elegans but is not essential for DNA replication or survival. BMC Dev. Biol. 5:24. 2005 (contains BMC Image of the Month)
Steele-Perkins, G., C. Plachez, K. G. Butz, G. H. Yang, C. J. Bachurski, S. L. Kinsman, E. D. Litwack, L. J. Richards and R. M. Gronostajski. The transcription factor gene Nfib is essential for both lung maturation and brain development. Mol. Cell. Biol. 25:685-98, 2005.
Ling, G., C. R. Hauer, R. M. Gronostajski, B. Pentecost, and X. Ding. Transcriptional regulation of rat CYP2A3 by nuclear factor 1: identification of a novel NFI-A isoform, and evidence for tissue-selective interaction of NFI with the CYP2A3 promoter in vivo. J. Biol. Chem. (2004)Butz, N. V., C. E. Campbell and R. M. Gronostajski. Differential target gene activation by TBX2 and TBX2VP16: evidence for activation domain-dependent modulation of gene target specificity. in press in Gene (2004).
Bachurski, C. J., G. H. Yang, T. A. Currier, R. M. Gronostajski, and D. Hong. Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Mol. Cell. Biol. 23 (2003) 9014-24.
Messam, C. A., J. Hou, R. M. Gronostajski, and E. O. Major. Lineage pathway of human brain progenitor cells identified by JC virus susceptability. Ann. Neurol. 53: 636-46, 2003.
Pan, L., Glenn, S.T., Jones, C.A., Gronostajski, R.M. and K.W. Gross. Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3. Biochim. Biophys. Acta. 1625:280-90, 2003.
Shu, T., K. G. Butz, C. Plachez, R. M. Gronostajski, and L. J. Richards. Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice. J. Neurosci. 23:203-12, 2003.
Steele-Perkins, G., K. G. Butz, G. E. Lyons, M. Zeichner-David, H.-J. Kim, M. I. Cho, and R. M. Gronostajski. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Mol. Cell. Biol. 23:1075-1084, 2003.
Gronostajski, R.M. Nuclear Factors, In: The Encyclopedia of Molecular Medicine, Wiley Press, New York, NY pp. 2290-1, 2002.
Gronostajski, R.M. Nuclear Factor I, In: The Encyclopedia of Molecular Medicine, Wiley Press, New York, NY pp. 2291-2, 2002.