Publications

 

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Recent Publications

We have provided you with links to PDF versions of the articles.  These are self-archived and available freely to all visitors to our web site.

Structure model of Fox1, an MCO from Chlamydomonas reinhardtii.  Although this file has a PDB extension and is readable by programs such as InsightII and Sybyl, because of the non-standard residue notation, it is not readable by freeware such as DeepView and PDBviewer.  To access this file please click here.

Jung, W. J., Sham, A., Singh, A., Kosman, D.J. and Kronstad, J.W.  (2008) Iron source preference and regulation of iron uptake in Cryptococcus neoformans.  Plos Path. 4, e45. [PDF]
Kosman, D.J.  (2008) Substrate entasis and electronic coupling elements in electron transfer from FeII in a multicopper oxidase. Inorgan. Chim. Acta 361:844-849. [PDF]
Singh, A. Kaur, N. and Kosman, D. J.  (2007) The metalloreductase Fre6p in Fe-efflux from the yeast vacuole.  J. Biol. Chem. 282:28619- 8626. [PDF]

Augustine, T. J., Stoj, C. S., Taylor, A. B., Hart, P. J., Kosman, D. J., and Solomon, E. I.  (2007)  Shall We Dance?  How a multicopper oxidase chooses its electron transfer partner.  Acc. Chem. Res. 40:445-452.      [PDF]

Stoj, C. S., Augustine, T. J., L., Solomon, E. I., and Kosman, D. J.  (2007)  Structure-function analysis of the cuprous oxidase activity in Fet3p from Saccharomyces cerevisiae.  J. Biol. Chem. 282:7862-7868. [PDF]

Stoj, C. S., Augustine, T. J., Zeigler, L., Solomon, E. I., and Kosman, D. J.  (2006)  The structural basis of the ferrous iron specificity of the yeast ferroxidase, Fet3p.  Biochemistry 45:12741-12749. [PDF] 

Kwok, E. Y., Severance, S. and Kosman, D. J. (2006) Evidence for iron channeling in the Fet3p, Ftr1p high affinity iron uptake complex in the yeast plasma membrane. Biochemistry, 45:6317-6327. [PDF] 

Singh, A., Severance, S. Kaur, N., Wiltsie, W. and Kosman, D. J. (2006) Assembly, activation and trafficking of the Fet3p, Ftr1p high affinity iron permease complex in Saccharomyces cerevisiae.  J. Biol. Chem., 281:13355-13364. [PDF] 

Kwok, E. Y., Stoj, C. S., Severance, S., and Kosman, D. J. (2006) An engineered bifunctional high affinity iron uptake protein in the yeast plasma membrane. J. Inorg. Biochem. 100:1053-1060.  [PDF] 

Taylor, A. B., Stoj, C. S., Ziegler, L., D. J. Kosman and P. J. Hart, (2005) The copper-iron connection in biology: the structure of the yeast metallo-oxidase, Fet3p.  Proc. Natl. Acad. Sci. U.S.A. 102:15459-15464. [PDF] 

Kwok, E., and Kosman, D. J.  (2005)  Iron in yeast: mechanisms involved in homeostasis. Top. Curr. Genet. 14:59-99. [PDF]

Stoj, C., and Kosman, D. J.  (2005) Copper Oxidases, in Encyclopedia of Inorganic Chemistry, 2nd Ed., pp. 1134-1159, R. B. King, ed, John Wiley  [PDF]

Quintanar, L., Stoj, C., Wang, T. P., Kosman, D. J., and Solomon, E. I.  (2005)  Role of aspartate 94 in the decay of the peroxide intermediate in the multicopper oxidase Fet3p.  Biochemistry 44:6081-6091. [PDF]

Severance, S., Chakraborty, S., and Kosman, D. J.  (2004)  The Ftr1p iron permease in the yeast plasma membrane: orientation, topology, and structure-function relationships.  Biochem. J. 380:487–496. [PDF]

Quintanar, L., Gebhard, M., Wang, T.-P., Kosman, D. J., and Solomon, E. I.  (2004)  Ferrous binding to the multicopper oxidases Saccharomyces cerevisiae Fet3p and human ceruloplasmin: contributions to ferroxidase activity. J. Amer. Chem. Soc.  126:6579-6589. [PDF]

Stoj, C., and Kosman, D. J.  (2003) Cuprous oxidase activity of yeast Fet3p and human ceruloplasmin: implication for function.  FEBS Lett., 554:422-426. [PDF]

Shi, X., Stoj, C., Romeo, A., Kosman, D. J., and Zhu, Z.  (2003) Fre1p Cu2+ reduction and Fet3p Cu1+ oxidation modulate copper toxicity in Saccharomyces cerevisiae. J. Biol. Chem.,278:50309-50315. [PDF]

Wang, T.-P., Severance, S., Quintanar, L., Solomon, E. I., and Kosman, D. J.  (2003)  Targeted suppression of the ferroxidase and iron trafficking activities of the multicopper oxidase, Fet3p, from Saccharomyces cerevisiae.  J. Inorg. Biol. Chem., 8:611-620.  [PDF]

Palmer, A. E., Quintanar, L., Severance, S., Wang, T-P., Kosman, D. J., and Solomon, E. I.  (2002)  Spectroscopic characterization and O2 reactivity of the trinuclear Cu cluster of mutants of the multicopper oxidase Fet3p.  Biochemistry, 41:6438-6448.  [PDF]

Romeo, A. S., Christen, L., Niles, E. G., and Kosman, D. J.  (2001)  Intracellular chelation of iron by bipyridyl inhibits DNA virus replication: Ribonucleotide Reductase maturation as a probe of intracellular iron pools, J. Biol. Chem., 276:24301-24308. [PDF]

Machonkin, T. E., Quintanar, L., Palmer, A. E., Hassett, R., Severance, S., Kosman, D. J. and Solomon, E. I. (2001)  Spectroscopy and reactivity of the type 1 copper site in Fet3p from Saccharomyces cerevisiae: Correlation of structure with reactivity in the multicopper oxidases.  J. Amer. Chem. Soc, 123:5507-5517. [PDF]

Hassett, R., Dix, D., Eide, D., and Kosman, D. J. (2000) Fet4p is a physiologically relevant low affinity copper transporter in Saccharomyces cerevisiae. Biochem. J., 351:477-484. [PDF].

Blackburn, N. J., Ralle, M., Hassett, R., and Kosman, D. J. (2000) Spectroscopic analysis of the trinuclear cluster in the Fet3 protein from yeast, a multinuclear copper oxidase.  Biochemistry, 39:2316-2324. [PDF]

Serpe, M., Joshi, A., and Kosman, D. J. (1999) Structure-function analysis of the protein-binding domains of Mac1p, a copper-dependent transcriptional activator of copper uptake in Saccharomyces cerevisiae. J. Biol. Chem. 274:29211-29219. [PDF] 

Joshi, A., Serpe, M., and Kosman, D. J. (1999) Evidence for (Mac1p)2·DNA ternary complex formation in Mac1p-dependent transactivation at the CTR1 promoter. J. Biol. Chem. 274:218-226. [PDF] 

Kosman, D. J., Hassett, R., Yuan, D. S., and McCracken, J. (1998) Spectroscopic characterization of the Cu(II) sites in the Fet3 protein, the multinuclear copper oxidase from yeast required for high affinity iron uptake. J. Amer. Chem. Soc. 120:4037-4038. [PDF].  

Hassett, R., Yuan, D. S., and Kosman, D. J. (1998) Spectral and kinetic properties of the Fet3 protein from Saccharomyces cerevisiae, a multinuclear copper ferroxidase enzyme. J. Biol. Chem. 273:23274-23282. [PDF] 
 

Some additional review articles from our lab that will provide you with an overview of some our work:

Kosman, D. J.  (2003)  Molecular mechanisms of iron uptake in fungi.  Mol. Microbiol., 47:1185-1197. [PDF]

Kosman, D. J.  (2002)  The yeast protein, Fet3p: The role of multicopper ferroxidases in iron metabolism.  In A Handbook of Copper Toxicology, Massaro, E. J. ed., pp.153-175. [PDF]

Kosman, D. J.  (2002)  Fet3p, Ceruloplasmin, and the role of copper in iron metabolism.  Advances in Protein Chemistry, J. S. Valentine and E. Gralla, Eds., Elsevier, pp. 221-269. [PDF]