FALL SEMESTER 2009

Course Coordinator:  Dr. Daniel Kosman (camkos@buffalo.edu)
BMS 503 Fall 2009 Class Schedule [PDF]

PART I - Dr. Daniel Kosman, Instructor

For all Part I material, please go to http://www.smbs.buffalo.edu/bch/Labs/Kosman/Teaching.htm

There you will find PDFs of reading assignments; useful internet links; study problems; and practice exam problems.

Dr. Sat Sinha's Section:

Sinha Lecture Schedule [PDF]
Class 1 [PDF]
Class 2 [PDF]
Class 3 [PDF]
Class 4 [PDF]
Class 5 [PDF]

Papers:
Holms, C., Tjian, R. (2000) Promoter-Selective Properties of the TBP-Related Factor TRF1. Science 288, 867-870 [PDF]
Narlikar, G.J., Fan, H-Y., Kingston, R.E. (2002) Cooperation Between Complexes that Regulate Chromatin Structure and Transcription. Cell 108, 475-487 [PDF]
Lee, T.I. & Young, R.A. (2000) Transcription of Eukaryotic Protein-Coding Genes. Annu. Rev. Genet 34, 77-137 [PDF]

PART IV - Dr. Laurie Read's Section:

Dr. Laurie Read
249 Biomedical Research Bldg.
829-3307
LREAD@buffalo.edu

Lecture Schedule 2009

Lecture 1—Monday, November 24   (RNA processing I)

Read in preparation for this class:

1.         Mathews, et al.  Biochemistry,  "Processing of eukaryotic messenger RNA", pages 1096-1100.

2.         Proudfoot, N.J., A. Furger, and M.J. Dye. 2002. “Integrating mRNA processing with transcription”. Cell 108:501-512. [PDF]

Lecture 1 pdf


Lecture 2—Monday, December 1   (RNA processing II)

Read in preparation for this class:

1.         Valcarcel, et al., 1993.  The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.  Nature 362: 171-175. [PDF]

            Note:  Be prepared to come to the front of the room and explain any figure in this paper to your classmates!  For each figure, be able to say:

            1.  What is the question they are asking?
            2.  What is the approach they used?
            3.  What are the results?
            4.  What is the conclusion?

Lecture 3—Wednesday, December 3 (Translation I)

Read in preparation for this class:

1.         Mathews, et al., Biochemistry;  most of Chapter 27 “Information decoding: Translation”, pp. 1027-1052.

2.         Maguire and Zimmerman, 2001.  The Ribosome in Focus.  Cell 104:813-816. [PDF]
            This is a nice, short, recent update.

Lecture 3 pdf
Lecture 3 ppt

Lecture 4—Friday, December 5   (Translation II)

Read in preparation for this class:

1.         Valencia-Sanchez, M.A., L. Jidong, G.J. Hannon, and R. Parker. 2006. Control of translation and mRNA degradation by miRNAs and siRNAs.  Genes and Development 20:515-524. [PDF]

Read the whole thing, but concentrate on sections regarding translation.

Lecture 4 pdf
Lecture 4 ppt



Dr. Read's PowerPoint Presentation