RESEARCH Areas

DNA helicase mechanism(s) used to process complex DNA structures

To understand these processes, we have selected two fascinating DNA helicases: RuvAB and RecG.
Genetic studies demonstrate that RecG and RuvAB have overlapping functions. Biochemical studies demonstrate that these enzymes can bind and process DNA structures thought to resemble recombination intermediates and synthetic Holliday junctions. The goal of our work on these two enzymes is to understand the biochemical mechanism(s) used by structurally distinct motors to process similar DNA structures.

RuvAB

RecG