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DOWNLOAD
- Ion Channel Analysis Softwares
Welcome
to download our programs for ion channel analysis! Two separate
versions are now available, one called IcE (ion channel explorer),
and the other QuB (Q-matrix at UB). They are basically identical
in terms of the underlying algorithms. But they differ in
the way they look as well as many accessory features. Historically,
QuB came into being priori to IcE and integrated our earlier
programs known as PRE, SKM, MIL and MPL. If you have been
a fan of QuB, you may stick to it. IcE is more recently developed,
with an interface similar tob Axon's pClamp8. If you are familiar
to pClamp8, you may try IcE. It can read and write abf files
directly.
The
programs are outcome of many years of research efforts supported
by NIH. Our purpose is to make it as a useful toolkit for
the general scientific community. If you use the programs
extensively in your data analysis, we ask you to cite our
papers. If you have any suggestion and feedback, please let
us know. We want to make the programs more generally useable.
Downloads:
(IcE includes some common system Dlls, but
you may need additional ones depending on your system.)
References:
·
Qin, F., A. Auerbach, and F. Sachs. 1996. Estimating single
channel kinetic parameters from idealized patch-clamp data
containing missed events. Biophys. J. 70:264-280.
·
Qin, F., A. Auerbach, and F. Sachs. 1997. Maximum likelihood
estimation of aggregated Markov processes. Proc. R. Soc.
Lond. B. 264:375-383.
·
Qin, F., A. Auerbach, and F. Sachs. 2000. A direct optimization
approach to hidden Markov modeling for signal channel kinetics.
Biophys. J. 79:1915-1927.
·
Qin, F., A. Auerbach, and F. Sachs. 2000. Hidden Markov Modeling
for Single Channel Kinetics with Filtering and Correlated
Noise. Biophys. J. 79:1928-1944.
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More stuff coming up soon -
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